It should be considered furthermore that the extracellular matrix plays an important role in the endocrine secretions of the adipocytes and the release of growth factors, such as e.g. The Transforming Growth factor Beta (TGF-â), the platelet Growth factor (PDGF) or the fibroblast growth factor (FGF), among others, all contained in the SVF (stromal growth factor). This complex is found in cellular secretions in the presence of an extracellular matrix.

The SVF contains the various proteins present in the extracellular matrix of adipose tissue, including the laminitis which is of great interest, thanks to its ability to stimulate the nerve regeneration.

The cellular composition of SVF includes from pre-adipocytes to endothelial cells, smooth muscle cells, together with pericytes, fibroblasts. In General, the SVF also contains blood cells that come from capillaries that spray fat cells. These include cells such as: erythrocytes, B lymphocytes and T lymphocytes, macrophages, monocytes, mast cells, natural killer (NK), hematopoietic stem cell and endothelial progenitor cells, just to name the major.

These last two types of cells, namely hematopoietic stem cells and endothelial progenitor cells, play a decisive role in sustaining the viability of existing blood vessels and thus contributing to the creation of new ones.

Our experts are convinced that these elements are the further necessary ingredients that constitute and act in the ' cocktail ' of the SVF, as adjuvants to further increase the effect of autologous transplantation of somatic adipose tissue. An important aspect to be considered, on which there is still to be discussed, is that inherent in the functionality of the ASC just isolated from those retained, or that have undergone subsequent expansive processes.

In Somatike High Biotechmed, we believe that this debate is of little importance because of the large number of ASC that we are able to collect with the tissues and methods we use, and therefore we have no need to resort to Expansive procedures for further growth. However, what is isolated from the aspirate alone has proved a little less effective than a patented activation medium, which acts as a stimulator of the well-known growth factor of stem cells; On this aspect, we are also dedicating some of our studies, clinical and laboratory.

The same hypothesis emerged from the observations on the use of selected plasma factors and extracted from the patient, within the same session of the treatment. It is certainly true, in our opinion, that the ASC require activation for the full functionality and observations mentioned above, and confirm that the theory that cells derived from adipose tissue-ADSC-, albeit of larger quantities, lie dormant Within the adipose tissue and therefore require effective stimuli for the activation of full functionality. And this, both in the location where they are located and in the case of the plant in additional locations, in order to trigger self-renewal through cell division and the formation of other types of cells through mechanisms of differentiation and transdifferentiation.

All this is among other things in line with the theory that ASC are called into action only when the tissues in which they reside are dying, or are damaged as a result of traumatic events or progressive morbid processes.

Somatike High Biotechmed operates in all fields to select all scientific evidence that is able to expand the quality of treatments, applying the most safe and effective systems for the best use of tissue extracts.